Blue Rubber Bleb Nevus Syndrome
Also known as: BRBNS
What is Blue Rubber Bleb Nevus Syndrome?
This syndrome is a rare disorder characterized by multiple venous malformations most commonly affecting the skin and gastrointestinal tract. BRBNS is important due to its potential for serious or fatal bleeding. Cutaneous manifestations include multiple, protuberant, dark blue, compressible blebs that range in size from a few millimeters to several centimeters in diameter. Three types of lesions have been described: blue, rubbery. Blood-filled sacs with a smooth or wrinkled surface that are easily compressible and promptly refill when pressure is released; large, disfiguring, cavernous lesions that may compress vital structures; and blue, irregular macules.
Lesions may be painful and increased sweating on the skin overlying the lesion may be noted.
GI symptoms may include rectal bleeding or dark stools, which may lead to anemia, fatigue, and in some severe cases, fatal hemorrhage due to spontaneous rupture. Skeletal lesions may lead to fractures and bone deformities, causing pain and difficulty walking. Although rare, blue rubber bleb nevi have been reported in most organs of the body.
Treatment for Blue Rubber Bleb Nevus Syndrome
Treatment is patient-centered and close follow-up with specialists depending on the organ system involved is key to optimizing care.
This page was last updated on: 1/9/2017 12:09:19 PM
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