Iron Chelation Therapy

Also known as: chelation therapy.

What is iron chelation therapy?

Iron chelation therapy is a treatment used to remove excess iron from the blood. When individuals have to get many blood transfusions, iron overload can become a problem for them. When people have sickle cell disease, iron chelation therapy in the form of deferoxamine (Jadenu) has been shown to enhance iron excretion and remove excess tissue iron in regularly transfused patients.

What happens during the treatment?

Older forms of iron chelation therapy come in the form of an infusion pump that must be worn for 8 to 12 hours in order to inject the medication into the body. Newer forms of iron chelation therapy come in a tablet form that is either taken with juice or water or simply swallowed once a day. These newer forms of iron chelation therapy have good tolerance and are becoming the preferred method of treatment. Jadenu is one of these tablet forms of iron chelation therapy.

Is any special preparation needed?

Tests are needed in advance to determine if iron chelation therapy treatment is needed. Some of the treatments, such as Jadenu, must be taken on an empty stomach.

What are the risk factors?

Dizziness, nausea, vomiting, diarrhea, rash and hearing or vision problems are potential side effects of iron chelation therapy.


Reviewed by: Athena C Pefkarou, MD

This page was last updated on: November 06, 2020 02:42 PM

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