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Nicklaus Children’s Hospital has several outpatient and urgent care centers throughout South Florida, including on-demand, virtual care.
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Also known as: hemoglobin H disease.
Hemoglobin H disease is a form of alpha thalassemia, a medical condition in which the body makes less hemoglobin than usual. There are four genes that contribute to the making of hemoglobin. When a person has a problem with three of these genes, the body begins to make an abnormal form of hemoglobin known as hemoglobin H, which can cause blood flow problems and anemia.
Hemoglobin H is a genetic disease, and the abnormal genes are passed along from parents to their children. A person must receive the genes from both parents in order to develop Hgb H disease.
Possible symptoms of Hgb H disease include anemia, jaundice, gallstones, growth retardation and an increased risk of infections.
Hgb H disease can be severe. Many people with the disease require regular blood transfusions and iron chelation in order to live a healthy life.
Reviewed by: Athena Pefkarou, MD
This page was last updated on: April 11, 2022 04:00 PM
Alpha thalassemia is an abnormality in the production of alpha chains which causes the red cells to more easily breakdown.
The gallbladder is a pear-shaped organ attached to the liver that stores bile. Gallstones are abnormal solid deposits made of cholesterol and biliary pigments. They are found inside the gallbladder.
Iron chelation therapy is a treatment used to remove excess iron from the blood.
A blood transfusion is when blood is infused into the body to replace missing blood.