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Also known as: DSDs, disorders of sex development
Disorders of sexual differentiation can refer to a wide range of different medical conditions that all impact the normal development of the baby’s sexual organs. They can range from sexual organs that don’t develop as fully as they should to the development of different-than-expected sexual organs that lead to questions about gender identity.
The most common DSDs are congenital adrenal hyperplasia and mixed gonadal dysgenesis; others include Androgen insensitivity syndrome (AIS), and Impaired testicular development. Most of these disorders are caused by genetic/ chromosomal abnormalities, though some may be idiopathic, where no cause can be found.
Children with DSDs have genitalia which are either ambiguous or malformed. A detailed discussion with your specialist pediatrician/geneticist/pediatric urological surgeon at Nicklaus Children's Hospital will enable you to understand the underlying abnormality present, its likely cause and the best treatment approaches, which may include medical and hormone therapy, reconstructive surgery and psychosocial support; to optimize the long term benefit for your baby and your family.
Reviewed by: Jack Wolfsdorf, MD, FAAP
This page was last updated on: October 21, 2021 11:01 AM
The adrenal glands are located above the kidneys and help with a number of essential bodily functions. When the adrenal glands do not produce cortisol, which is the stress hormone, the glands become enlarged and produce more testosterone, the male hormone. Learn more
Mixed gonadal dysgenesis is a sex developmental disorder where the gonads are abnormal from there being some cells with XY chromosomes and some with just a single X, ,known as chromosome Y mosaicism. Learn more