Also known as: BWS
What is Beckwith-Wiedemann Syndrome?
Beckwith-Wiedemann syndrome was first described by doctors Bruce Beckwith and Hans Rudolph Wiedemann in the 1960’s. The doctors identified children who had a number of symptoms including body overgrowth, external intestines, enlarged tongues, and low blood sugar. When a child exhibited all of these characteristics, they described them as having Beckwith-Wiedemann syndrome. Today, approximately 1 in 13,700 people have the condition.
What are the clinical characteristics of BWS?
- Macroglossia (large tongue)
- Macrosomia (large body size) and/or hemihypertrophy (one side of body is bigger than the other side)
- Neonatal hypoglycemia (low blood sugar as newborn babies)
- Increased risk for certain types of tumors such as Wilm's tumor (kidney tumor) and hepatoblastoma (liver tumor)
- Omphalocele (born with intestines on the outside of the body) or umbilical hernia
- Creases or pits on the ears
- Normal intelligence
What causes Beckwith-Wiedemann in children?
Beckwith-Wiedemann is a result of abnormal activity in the genes that regulate the body’s cell growth. While there is no single cause for the change of these genes, a geneticist can determine the source with special testing and evaluation. Most individuals with Beckwith-Wiedemann are the first affected in the family and the risk for recurrence is low. However, there may be a hereditary connection depending on the underlying cause.
What is the prognosis for my child with Beckwith-Wiedemann?
The prognosis for most children with this condition is generally positive, and treatment varies by child. It is important to monitor your child’s tumor development, but most children with Beckwith-Wiedemann will attend school, have friends, and enjoy life. With close follow-up by the craniofacial team and/or clinical geneticists at Nicklaus Children’s Hospital, your child can grow to become a healthy and happy adult.
Reviewed by: Chad Perlyn, MD
This page was last updated on: 1/9/2020 10:04:29 AM
Date: Friday, July 10, 2020
Nicklaus Children’s Hospital invites you to attend a conference designed to provide individuals with Beckwith-Wiedemann Syndrome (BWS) and their families with up-to-date information about the possible aspects of BWS and their management.
Dr. Chad Perlyn is a pediatric plastic surgeon with the Division of Plastic Surgery at Nicklaus Children's Hospital. For more information, please visit nicklauschildrens.org/BWS
Patient Success Stories
Alyssa Caulley talks about her experiences at Nicklaus Children's Hospital, where she decided to have her daughter's surgery for Beckwith Wiedemann Syndrome (BWS).
Learn more about
Macroglossia is the medical term for when a child is born with an enlarged tongue. It is one of the most common features of Beckwith-Wiedemann Syndrome (BWS), affecting around 90 percent of children with the congenital disorder.
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