CLOVES Syndrome

Also known as: CLOVE syndrome, CS, congenital lipomatous overgrowth, vascular malformations, epidermal nevis and scoliosis/skeletal/spinal anomalies.

What is CLOVES syndrome?

CLOVES syndrome is a very rare disorder, one of a group of congenital (present at birth) “overgrown syndromes”, that is characterized by the presence of several problems together. CLOVES stands for:
  • Congenital
  • Lipomatous
  • Overgrowth
  • Vascular
  • Epidermal Nevis
  • Spinal / Skeletal / Anomalies / Scoliosis


This disorder includes: large collections (masses) of fatty tissue, complex vascular malformations, patches of overgrown skin, spine problems, other bone and joint abnormalities and stiff or weak muscles.

 

What causes CLOVES syndrome?

CLOVES syndrome is due to a genetic mutation that occurs while a fetus is developing in the womb. It does not appear to run in families.

 

What are signs/the symptoms of CLOVES syndrome?

Signs and symptoms of CLOVES syndrome include:

  • Soft fatty masses seen at birth, affecting one or both sides of the body, frequently located in the abdomen, buttocks, flanks, armpits, and back.
  • Vascular abnormalities, such as include dilated veins on arms and legs, and abnormalities of lymphatic vessels.
  • Large wide hands or feet and other abnormalities of the arms and legs are common.
  • Skin birthmarks
  • Spinal anomalies like scoliosis (curved spine)
  • Kidney problems

 

What are CLOVES syndrome care options?

As there are a wide range of problems and complications, a team of pediatric specialists and subspecialists is required to deliver optimal care.


Reviewed by: Jack Wolfsdorf, MD

This page was last updated on: 8/24/2017 4:18:35 PM

From the Newsdesk

Baby Grace Beats All Odds Despite Rocky Start to Life
08/28/2017 — Grace was transferred to Nicklaus Children’s for what referring doctors believed were complications associated with neonatal sepsis. Soon after, the care team learned Grace had an enlarged failing heart due to hypoplastic left heart syndrome, a complex congenital heart defect that essentially means the baby was born with half a heart. 
Free EKG Screening for Student Athletes
08/17/2017 — Every 3 days, the life of a young athlete is lost due to sudden cardiac death. Usually, there are no advanced signs or symptoms. But the saddest part is that it's entirely preventable. A simple EKG screenig can detect heart problems before it's too late. Miami Children's Hospital is offering this invaluable test free of charge to middle and high school sports participants.

Back
To Top