NEMO Syndrome

Also known as: Nuclear factor-kappa B Essential Modulator deficiency syndrome, NEMO deficiency syndrome.

What is NEMO syndrome?

NEMO syndrome is a rare genetic disease that impacts the immune system that  predisposes the patient to frequent and serious infections, it also causes problems related to the skin, as well as the lungs, stomach and urinary tract in some instances.

What causes NEMO syndrome? 
It is a genetic defect caused by a mutation in the Nuclear factor-kappa B Essential Modulator (NEMO) gene. Why this mutation occurs isn’t exactly clear.

What are the symptoms of NEMO syndrome? 
The most common symptoms of NEMO syndrome include an inability to fight off diseases, thick skin, few sweat glands, abnormal teeth and thin hair. A number of other symptoms can occur in some instances.

What are NEMO syndrome care options? 
Immunoglobulin therapy can help boost immunity in children with NEMO syndrome. Antibiotics and other medications may be needed to help the child fight infections. In severe cases, a stem cell transplant may help with the condition.

Reviewed by: Jose G. Calderon, MD

This page was last updated on: 6/21/2019 2:24:48 AM