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To inquire about current studies please contact Miami Children's Research Institute  at:


List of Clinical Research Studies Nicklaus Children's Hospital is participating in:

Recruiting:

Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

Conditions: Recurrent Childhood Medulloblastoma;   Recurrent Childhood Ependymoma;   Childhood Atypical Teratoid/Rhabdoid Tumor;   Embryonal Tumor With Abundant Neuropil and True Rosettes;   Metastatic Malignant Neoplasm to the Leptomeninges
Interventions: Drug: Intra thecal methotrexate;   Drug: topotecan;   Drug: cyclophosphamide
Age: up to 22 Years   (Child, Adult)
Study Start: February 2016
Study Completion: February 2020
Conditions: Hypofibrinogenemia;   Afibrinogenemia;   Bleeding Disorders
Interventions: Drug: RiaStAP;   Drug: Saline
Age: up to 1 Year   (Child)
Study Start: January 2017
Study Completion: April 2019
Condition: Benign Centrally-Located Intracranial Tumors
Intervention: Device: ExAblate 4000 System
Age: 8 Years to 22 Years   (Child, Adult)
Study Start: January 12, 2017
Study Completion: January 15, 2019
Not yet recruiting:

COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction

Conditions: Pulmonary Valve Insufficiency;   Pulmonary Valve Stenosis;   Heart Defects, Congenital;   Congenital Abnormalities;   Cardiovascular Diseases;   Heart Diseases
Intervention: Device: SAPIEN XT THV
Age: 19 Years and older   (Adult, Senior)
Study Start: May 2017
Study Completion: January 2024
Condition: Epilepsy
Interventions: Drug: cannabidiol;   Other: Blood Test
Age: 2 Years to 16 Years   (Child)
Study Start:  
Study Completion:  
Condition: Epilepsy
Intervention: Drug: Ganaxolone
Age: 2 Years to 18 Years   (Child, Adult)
Study Start: March 2015
Study Completion: July 2018
Condition: Hyperphosphatemia
Interventions: Drug: PA21 (Velphoro®);   Drug: Calcium Acetate (Phoslyra®)
Age: up to 18 Years   (Child, Adult)
Study Start: June 2016
Study Completion:  
Conditions: Germ Cell Tumor;   Teratoma;   Choriocarcinoma;   Germinoma;   Mixed Germ Cell Tumor;   Yolk Sac Tumor;   Childhood Teratoma;   Malignant Germ Cell Neoplasm;   Extragonadal Seminoma;   Non-seminomatous Germ Cell Tumor;   Seminoma
Interventions: Drug: paclitaxel;   Drug: ifosfamide;   Drug: cisplatin;   Drug: pegylated G-CSF;   Drug: G-CSF;   Drug: carboplatin;   Drug: etoposide phosphate;   Procedure: stem cell reinfusion
Age: 14 Years and older   (Child, Adult, Senior)
Study Start: March 2015
Study Completion:  
Condition: Persistent Pulmonary Hypertension of the Newborn
Interventions: Drug: IV Remodulin;   Drug: Placebo
Age: up to 14 Days   (Child)
Study Start: May 2015
Study Completion: January 2018
Conditions: Ganglioneuroblastoma;   Recurrent Neuroblastoma
Interventions: Biological: Dinutuximab;   Drug: Irinotecan Hydrochloride;   Other: Laboratory Biomarker Analysis;   Biological: Sargramostim;   Drug: Temozolomide;   Drug: Temsirolimus
Age: Child, Adult, Senior
Study Start: February 2013
Study Completion:  
Conditions: PRETEXT Stage 1 Hepatoblastoma;   PRETEXT Stage 2 Hepatoblastoma;   PRETEXT Stage 3 Hepatoblastoma;   PRETEXT Stage 4 Hepatoblastoma
Interventions: Drug: Cisplatin;   Drug: Doxorubicin Hydrochloride;   Drug: Fluorouracil;   Drug: Irinotecan Hydrochloride;   Other: Laboratory Biomarker Analysis;   Procedure: Liver Transplantation;   Drug: Temsirolimus;   Procedure: Therapeutic Conventional Surgery;   Drug: Vincristine Sulfate
Age: up to 21 Years   (Child, Adult)
Study Start: September 2009
Study Completion:  
Conditions: Classical Hodgkin Lymphoma;   Stage IIB Hodgkin Lymphoma;   Stage IIIB Hodgkin Lymphoma;   Stage IVA Hodgkin Lymphoma;   Stage IVB Hodgkin Lymphoma
Interventions: Biological: Bleomycin Sulfate;   Drug: Brentuximab Vedotin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Prednisone;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Vincristine Sulfate
Age: 2 Years to 18 Years   (Child, Adult)
Study Start: March 2015
Study Completion:  
Conditions: B Acute Lymphoblastic Leukemia;   Bone Necrosis;   Central Nervous System Leukemia;   Cognitive Side Effects of Cancer Therapy;   Neurotoxicity Syndrome;   Pain;   Testicular Leukemia;   Therapy-Related Toxicity;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Drug: Clofarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dasatinib;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Age: 1 Year to 30 Years   (Child, Adult)
Study Start: February 2012
Study Completion:  
Recruiting:

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

Conditions: Disseminated Neuroblastoma;   Ganglioneuroblastoma;   Localized Resectable Neuroblastoma;   Localized Unresectable Neuroblastoma;   Regional Neuroblastoma;   Stage 4S Neuroblastoma
Interventions: Other: laboratory biomarker analysis;   Other: cytology specimen collection procedure
Age: up to 30 Years   (Child, Adult)
Study Start: November 2000
Study Completion:  
Recruiting:

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Conditions: Adult B Lymphoblastic Lymphoma;   Childhood B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1;   Childhood B Lymphoblastic Lymphoma;   Down Syndrome;   Stage I B Lymphoblastic Lymphoma;   Stage II B Lymphoblastic Lymphoma;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Age: 1 Year to 30 Years   (Child, Adult)
Study Start: August 2010
Study Completion:  
Conditions: Adult B Acute Lymphoblastic Leukemia;   Adult T Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia;   Childhood T Acute Lymphoblastic Leukemia;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Other: Cytology Specimen Collection Procedure;   Other: Laboratory Biomarker Analysis
Age: up to 30 Years   (Child, Adult)
Study Start: August 2010
Study Completion:  
Condition: Juvenile Idiopathic Arthritis
Interventions: Drug: CP-690,550 (tofacitinib);   Other: placebo
Age: 2 Years to 17 Years   (Child)
Study Start: June 10, 2016
Study Completion: April 29, 2019
Conditions: Leukemia Cutis;   Myeloid Sarcoma;   Untreated Adult Acute Myeloid Leukemia;   Untreated Childhood Myeloid Neoplasm
Interventions: Drug: Asparaginase;   Drug: Bortezomib;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Sorafenib Tosylate
Age: up to 29 Years   (Child, Adult)
Study Start: June 2011
Study Completion:  
Conditions: Metastatic Ewing Sarcoma;   Metastatic Malignant Neoplasm in the Bone;   Metastatic Malignant Neoplasm in the Bone Marrow;   Metastatic Malignant Neoplasm in the Lung;   Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone;   Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Interventions: Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Radiation: External Beam Radiation Therapy;   Biological: Ganitumab;   Drug: Ifosfamide;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Radiation: Stereotactic Radiosurgery;   Procedure: Therapeutic Surgical Procedure;   Drug: Vincristine Sulfate
Age: up to 50 Years   (Child, Adult)
Study Start: December 2014
Study Completion:  
Conditions: Adult T Acute Lymphoblastic Leukemia;   Childhood T Acute Lymphoblastic Leukemia;   Stage II Childhood Lymphoblastic Lymphoma;   Stage II Contiguous Adult Lymphoblastic Lymphoma;   Stage II Non-Contiguous Adult Lymphoblastic Lymphoma;   Stage III Adult Lymphoblastic Lymphoma;   Stage III Childhood Lymphoblastic Lymphoma;   Stage IV Adult Lymphoblastic Lymphoma;   Stage IV Childhood Lymphoblastic Lymphoma;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Drug: Bortezomib;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Drug: Ifosfamide;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Age: 2 Years to 30 Years   (Child, Adult)
Study Start: September 2014
Study Completion:
 

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