Steven Melnick, PhD, MD


Chief, Department of Pathology

Dr. Melnick, serves as the Principal Investigator and the Medical Director of the Nicklaus Children’s Biobank (NCB) with responsibility for oversight of all aspects of this project and for assuring compliance with all policies and procedures by NCB staff.

Dr. Melnick received a B.Sc. degree in Physics at McGill University, Montreal, Quebec. Later he pursued a doctoral research in Chemical Physics and earned a Ph.D., at McGill University, Department of Chemistry in the field of nuclear quadrupole resonance spectroscopy. Following a Post-doctoral Fellowship in the same field, he began Medical School at Queen’s University, Kingston, Ontario and subsequently, residency training in Pathology at Mount Sinai Medical Center, Miami Beach, Florida.

He continued his career in medicine as an attending Pathologist at Miami Children’s Hospital (now Nicklaus Children’s Hospital). In addition to his clinical activities, he established a research program in cell and molecular biology, with a particular focus on cancer research including ethnobotanical drug discovery. Currently, Dr. Melnick serves as Chief, Department of Pathology and Clinical laboratories at Nicklaus Children’s Hospital.

Huerta, C.T., Quinn, K., ..., Melnick, S.J., et al (2023). Peripheral vascular bypass with cadaveric arterial allograft in a toddler with femoral mycotic aneurysm. Journal of surgical case reports, 2023(4), rjad198. View in Pubmed

Totapally, B., Nadiger, M., ..., Melnick, S. (2021). Identification of Multisystem Inflammatory Syndrome in Children Classes and Development of Hyperinflammation Score in Pediatric COVID-19. Journal of Pediatric Intensive Care, 12(2), 137-147. View in Pubmed

Krishnamurthy, K., Febres-Aldana, C.A., Melnick, S., et al (2021). Morphological and immunophenotypical analysis of the spindle cell component in adenomyomatous hyperplasia of the gallbladder. Pathologica, 113(4), 272-279. View in Pubmed

Ramachandran, C., Portalatin, G.M., Prado, A.M., Quirin, K.W., Escalon, E., Melnick, S.J. (2017). In Vivo Antitumor Effect of Supercritical CO2 Extract of Mango Ginger (Curcuma amada Roxb) in U-87MG Human Glioblastoma Nude Mice Xenografts. Journal of Evidence-Based Complementary & Alternative Medicine, 22(2), 260-267. View in Pubmed

Ramachandran, C., Lollett, I.V., Escalon, E., Quirin, K.W., Melnick, S.J. (2015). Anticancer potential and mechanism of action of mango ginger (Curcuma amada Roxb.) supercritical CO₂ extract in human glioblastoma cells. Journal of Evidence-Based Complementary & Alternative Medicine, 20(2), 109-119. View in Pubmed

Ramachandran, C., Portalatin, G., Quirin, K.W., Escalon, E., Khatib, Z., Melnick, S.J. (2015). Inhibition of AKT signaling by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cells. Journal of complementary & integrative medicine, 12(4), 307-315. View in Pubmed

Ramachandran, C., Quirin, K.W., Escalon, E.A., Lollett, I.V., Melnick, S.J. (2015). Therapeutic Effect of Supercritical CO2 Extracts of Curcuma Species with Cancer Drugs in Rhabdomyosarcoma Cell Lines. Phytotherapy research, 29(8), 1152-1160. View in Pubmed

Ramachandran, C., Quirin, K.W., Escalon, E., Melnick, S.J. (2014). Improved neuroprotective effects by combining Bacopa monnieri and Rosmarinus officinalis supercritical CO2 extracts. Journal of Evidence-Based Complementary & Alternative Medicine, 19(2), 119-127. View in Pubmed

Tashiro, J., Perlyn, C.A., Melnick, S.J., Gulec, S.A., Burnweit, C.A. (2014). Non-pigmented melanoma with nodal metastases masquerading as pyogenic granuloma in a 1-year old. Journal of Pediatric Surgery, 49(4), 653-655. View in Pubmed

Rachmut, I., Samuels, N., Melnick, S.J., et al (2013). Immunomodulatory effects of the botanical compound LCS101:implications for cancer treatment.. OncoTargets and Therapy, 6(), 437-445. View in Pubmed

Ramachandran C., Nair S.M., Quirrin K-W, Melnick S.J. (2013). Hypolipidemic Effects of a Proprietary Commiphora Mukul Gum Resin Extract and Medium-Chain Triglyceride Preparation (GU-MCT810).. Journal of Evidence-Based Complementary & Alternative Medicine, 18(), 248-256.

Ramachandran, C., Nair, S.M., Escalon, E., Melnick, S.J. (2012). Potentiation of etoposide and temozolomide cytoxicity by curcumin and turmeric force in brain tumor cell lines. Journal of Complementary & Integrative Medicine, 9(1), Article 20. View in Pubmed

Ramachandran, C., Nair, S.M., Quirrin, K.W., Escalon, E., Melnick, S.J. (2012). Adjuvant therapeutic use of supercritical-ethanol extracts of Curcuma species with cancer drugs in rhabdomyosarcoma. Planta Medica, 78(), 1174.

Aviram, A., Tsoukias, N.M., Melnick, S.J., Resek, A.P., Ramachandran, C. (2012). Inhibition of nitric oxide synthesis in mouse macrophage cells by feverfew supercritical extract. Phytotherapy Research, 26(4), 541-545. View in Pubmed

Ramachandran, C., Quirin, K.W., Resek, A., Melnick, S.J. (2012). Protective and restorative effects of a Commiphora mukul gum resin and triheptanoin preparation on the CCL-110 skin fibrolast cell line. International Journal of Cosmetic Science, 34(2), 155-160. View in Pubmed

Ramachandran, C., Wilk, B.J., Hotchkiss, A., Chau, H., Eliaz, I., Melnick, S.J. (2011). Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin. BMC Complementary and Alternative Medicine, 11(), 59. View in Pubmed

Melnick, S.J., Motheral, B.R. (2010). Is value-based value wasted? Examining value-based insurance designs through the lens of cost-effectiveness. Journal of Managed Care Pharmacy, 16(2), 130-133. View in Pubmed

Ramachandran, C., Resek, A.P., Escalon, E., Aviram, A., Melnick, S.J. (2010). Potentiation of gemcitabine by Turmeric Force in pancreatic cancer cell lines. Oncology Reports, 23(6), 1529-1535. View in Pubmed

Nair, P.K., Melnick, S.J., Wnuk, S.F., Rapp, M., Escalon, E., Ramachandran, C. (2009). Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium. Journal of Ethnopharmacology, 122(3), 450-456. View in Pubmed

Cochrane, C.B., Nair, P.K., Melnick, S.J., Resek, A.P., Ramachandran, C. (2008). Anticancer effects of Annona glabra plant extracts in human leukemia cell lines. Anticancer Research, 28(2A), 965-971. View in Pubmed

Luo, J., Melnick, S., Rossi, A., Burke, R.P., Pfeifer J.D., Dehner, L.P. (2008). Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration. Pediatric and Developmental Pathology, 11(2), 142-147. View in Pubmed

Qiu, J., Ai, L., Ramachandran, C., Yao, B., Gopalakrishnan, S., Fields, C.R., Melnick, (2008). Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. Laboratory Investigation, 88(9), 910-925. View in Pubmed

Rogers, P.C., Melnick, S.J., Ladas, E.J., Halton, J., Baillargeon, J., Sacks, N., et al. (2008). Children's Oncology Group (COG) Nutrition Committee. Pediatric Blood & Cancer, 50(Suppl 2), 447-450; discussion 451. View in Pubmed

Primary Office

MCH Pathologists,PA
3100 SW 62 Avenue
Miami, FL 33155
Phone Number:


Residency - Mt.Sinai Medical Center,Miami Beach
Medical School - Queen's University, Ontario, Canada

Board Certifications

American Board of Pathology (Anatomic & Clinical Path) - Certified