Cerebrocostomandibular Syndrome

Also known as: CCM syndrome, CCMS.

What is cerebrocostomandibular syndrome?

Cerebrocostomandibular syndrome is an extremely rare congenital disorder that impacts the jaw and mouth. Infants with the disease have a small jaw (micrognathia), malformations of the roof of the mouth (cleft palate), malposition of the tongue (glossoptosis) and abnormal development of the ribs (rib dysplasia).

What causes cerebrocostomandibular syndrome?

The cause of cerebrocostomandibular syndrome is not entirely clear. There may be a genetic component to the disease, and it appears to run in families in some cases.

What are the symptoms of CCMS?

The abnormal rib development can cause breathing difficulties for the infant. Defects of the roof of the mouth can cause feeding and speech difficulties. Most individuals affected by this syndrome exhibit normal intelligence. However, some can have delay in mental development.

What are CCMS care options?

Many specialists may be involved in the care of infants with cerebrocostomandibular syndrome, particularly for the immediate concerns of breathing and feeding. Though there is no cure for the disease, there are several therapies and surgical options that can help children with the disease.


This page was last updated on: June 30, 2021 11:18 AM

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Cleft Lip and/or Palate

A cleft lip and/or palate is characterized by the presence of a gap (split) in the lip and/or palate seen at birth when the tissues of the lip and/or palate don't come together at all, or come together only part of the way. Learn more

Micrognathia

Micrognathia is the medical term for an undersized jaw. It is typically present along with other birth defects and facial abnormalities. Learn more