Langerhans cell histiocytosis
Also known as: LCH, childhood Langerhans cell histiocytosis, diffuse reticuloendotheliosis, eosinophilic granuloma , histiocytosis x and others.
What is Langerhans cell histiocytosis?
Langerhans cell histiocytosis (LCH) is a rare disease of children ( most commonly between the ages of 1-3 years; boys more often than girls) in which a certain immature normal white blood type ( Langerhans cells, a type of histiocyte ) grows uncontrollably and rapidly in almost any organ ( there appears to be debate as to whether this is a form of cancer or not ).
What causes Langerhans cell histiocytosis?
The cause is unknown, however gene mutations have been found in about half the patients.
What are the symptoms of Langerhans cell histiocytosis?
Symptoms depend on which tissue/s or organ/s the cell multiplies in. They include fever, weakness and tiredness, bone involvement ( 78% ) which often presents as swelling or a lump, or fractures of bone that occur for no reason ( or small injury ), skin rashes ( 50% of patients ), lung damage ( ~ 20-40% ), swollen lymph nodes ( ~ 30% ), ear infections, liver problems and many others.
What are Langerhans cell histiocytosis care options?
Children with localized disease may require no treatment. In some cases, surgery to remove the tumor, low-dose radiation therapy and chemotherapy may be utilized.
Reviewed by: Jack Wolfsdorf, MD, FAAP
This page was last updated on: 10/31/2017 11:54:36 AM
From the Newsdesk
Meet our July Patient of the Month, Lacy. Lacy was only 2 years old when her parents noticed that something was wrong. They took her to various doctors to try to find what could be the cause, Lacy had an 8 cm. tumor in her brain, occupying most of the lower part of her head.
At a young age, Bi’Yanie was diagnosed with sickle cell, a blood disorder that causes the cells to take on a crescent or sickle shape and can lead to very painful episodes called crises. Today, Bi’Yanie is getting stronger by the day, thanks to the bone marrow transplant she received at Nicklaus Children’s Hospital.