MIAMI, FL — Miami Children’s Hospital is a key member of a nationwide group of medical centers that have been awarded a $17 million grant from the
National Institute of Neurologic Disorders and Stroke – a division of the National Institutes of Health – for a clinical research study of childhood absence (petit mal) epilepsy.
The grant funds a comparison of the three most commonly used anti-epileptic drugs for absence seizures, which account for 10 to 15 percent of all cases of epilepsy in children. The goal is to determine the best initial medicine for childhood absence epilepsy. The five-year study will enroll 439 children – ages 2 to 13 – at 20 sites throughout the country. Miami Children’s Hospital is one of these sites.
The grant is the largest ever awarded for a clinical research study of pediatric epilepsy, and the clinical trial will be the largest head-to-head comparison of available drugs for the treatment of pediatric epilepsy trial ever conducted, said
Michael Duchowny, M.D., Director of the
Comprehensive Epilepsy Program at MCH.
In addition to the clinical trial, the grant funds pharmacokinetic and pharmacogenetic research on how these medicines act in children with childhood absence epilepsy. Pharmacokinetics is the study of how the body absorbs, distributes, metabolizes and excretes drugs. Pharmacogenetics is the study of genetic determinants of the response to drugs.
“We want to identify the factors underlying individual variations. Why do some drugs succeed and others fail in some patients? Why do some have side effects while others do not? And what are the effects on cognition, behavior and learning?” said Dr. Duchowny. “This is the first step toward our goal of making it possible for physicians to predict patient response and tailor childhood epilepsy therapies for individual needs.”
About Nicklaus Children's Hospital, Where Children Matter Most ™ (2024)
Nicklaus Children's Hospital is South Florida's #1 nonprofit, freestanding specialty licensed hospital exclusively for children. With more than 850 physicians, including over 500 pediatric subspecialists, the hospital and its network of outpatient centers and offices serve close to 70% of children in the Miami market. The only hospital "where your child matters most™,” Nicklaus Children's is home to the region's most advanced Kenneth C. Griffin Surgical Tower, and its centers of excellence Helen & Jacob Shaham Cancer & Blood Disorders Institute, the Nicklaus Children’s Orthopedics, Sports Health and Spine Institute, Nicklaus Children’s Brain Institute and Nicklaus Children’s Heart Institute. The Nicklaus Children's Hospital's Transfer Center, Nick4Kids, and LifeFlight are responsible for transporting and saving close to 5,000 lives a year. Our 307-bed hospital, which is renowned for excellence in all aspects of pediatric medicine, has many specialty programs routinely ranked among the best in the nation by U.S. News & World Report since 2008. Nicklaus Children's is also home to the largest pediatric teaching program in the southeastern United States and since 2003 has been designated an American Nursing Credentialing Center (ANCC) Magnet facility, the nursing profession's most prestigious institutional honor. For more information, please visit www.nicklauschildrens.org.