Primary Office

Address:
Kidz Medical Services, Inc.
3100 SW 62 Avenue -NE Wing #121
Miami, FL 33155
Phone Number: 305-662-8360

Education

Residency - Jackson Memorial Hospital
Medical School - American Univ. of Beirut, Lebanon
Fellowship - St. Jude Children's Research Hosp.

Board Certifications

American Board of Pediatrics (Ped Hemat-Onc) - Certified


Director, Neuro-Oncology Program
Vice President of Medical Staff

Dr. Khatib received his medical degree from American University of Beirut, Lebanon. He completed his residency at Jackson Memorial Hospital in Miami and a fellowship in hematology-oncology at St. Jude Children’s Research Hospital in Memphis, Tennessee. Dr. Khatib is a fellow of the American Academy of Pediatrics and a member of the American Society of Hematology, American Society of Clinical Oncology, American Society of Pediatric Hematology Oncology, and the Society of Neuro-Oncology.

Dr. Khatib is the Director of NeuroOncology at Nicklaus Children’s Hospital- Miami where he has been practicing for over 24 years. He is a clinical associate professor at Florida International University Herbert Wertheim College of Medicine.

He participates in conducting research studies involving children with brain tumors and testing new approaches for cancer treatment.
 

Areas of Specialty:

  1. Brain tumors in children
  2. Vascular and lymphatic malformations
  3. Stroke and thrombosis
  4. Cancer genetics
  5. Complimentary and integrative approaches to brain tumors

Research Studies:

  1. Study of Genetic Markers for Anthracycline Toxicity in Children with Cancer- Principal Investigator
  2. Pilot Dose Escalation Evaluation of Adjuvant Curcuma Amada (Mango Ginger) Supercritical CO2 Extract with Combination Chemotherapy in Patients with Solid Tumors
  3. Phase II Study of MEK 162 for Children with Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors
  4. THE “HEAD START 4” Protocol - Newly Diagnosed Children (Less than 10 years Old) with Medulloblastoma and other Central Nervous System Embryonal Tumors: Clinical and Molercular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with Either Single Cycle (Low Risk Patients) Or Randomization (High Risk Patients) to Either Single Cycle Or To Thee Tandem Cycles of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue.
  5. Principal investigator: A Phase II Study of Methotrexate Infusions into the Lateral or Fourth Ventricle in Children with Malignant Brain Tumors
  6. Study Ketogenic Diet in Pediatric Brain Tumors

Publications

Hall, M.D., Odia, Y., Allen, J.E., Tarapore, R., Khatib, Z., Niazi, T.N., et al (2019). First clinical experience with DRD2/3 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report. Journal of Neurosurgery. Pediatrics, View in Pubmed

Shah, A.H., Khatib, Z., Niazi, T. (2018). Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review. Child's nervous system, 34(4), 649-654. View in Pubmed

Pekmezci, M., Villanueva-Meyer, J.E., Goode, B., ..., Khativ, Z., et al (2018). The genetic landscape of ganglioglioma.. Child's nervous system, 6(1), 47. View in Pubmed

Capper, D., Jones, D.T.W., Sill, M., ..., Khatib, Z., et al (2018). DNA methylation-based classification of central nervous system tumours. Nature, 555(7697), 469-474. View in Pubmed

Gupta, N., Goumnerova, L.C., Manley, P., Chi, S.N., ..., Khatib, Z., et al (2018). Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro-oncology, 20(11), 1547-1555. View in Pubmed

Pekmezci, M., Villanueva-Meyer, J.E., Goode, B., Van Ziffle, J., ..., Khatib, Z., et al (2018). The genetic landscape of ganglioglioma. Acta neuropathologica communications, 6(1), 47. View in Pubmed

Goyal, A., Cajigas, I., Ibrahim, G.M., Brathwaite, C.D., Khatib, Z., et al (2018). Surgical Treatment of Intramedullary Spinal Metastasis in Medulloblastoma: Case Report and Review of the Literature. World neurosurgery, 118(), 42-46. View in Pubmed

Shah, A.H., Khatib, Z., Niazi, T. (2018). Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review. Child's nervous system, 34(4), 649-654. View in Pubmed

Ramachandran, C., Portalatin, G., Quirin, K.W., Escalon, E., Khatib, Z., Melnick, S.J. (2015). Inhibition of AKT signaling by supercritical CO2 extract of mango ginger (Curcuma amada Roxb.) in human glioblastoma cells. Journal of complementary & integrative medicine, 12(4), 307-315. View in Pubmed

Luna, B., Bhatia, S., Yoo, C., Felty, Q., Sandberg, D.I., Duchowny, M., Khatib, Z., Miller, I., Ragheb, J., Prasanna, J., Roy, D. (2015). Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. Molecular Neourobiology, 52(3), 1341-1363. View in Pubmed

Luna, B., Bhatia, S., Yoo, C., Felty, Q., Sandberg, D.I., Duchowny, M., Khatib, Z., Miller, I., Ragheb, J., Prasanna, J., Roy, D. (2014). Bayesian Network and Mechanistic Hierarchical Structure Modeling of Increased likelihood of Developing Intractable Childhood Epilepsy from the Combined Effect of mtDNA Variants, Oxidative Damage, and Copy Number. Journal of Molecular Neuroscience, 54(4), 752-766.

Luna, B., Bhatia, S., Yoo, C., Felty, Q., Sandberg, D.I., Duchowny, M., Khatib, Z., Miller, I., Ragheb, J., Prasanna, J., Roy, D. (2014). Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors. Molecular Neurobiology, [E-Publication, ahead of print](), . View in Pubmed

Robison, N.J., Campigotto, F., Chi, S.N., ..., Khatib, Z.A., et al (2014). A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer. Pediatric Blood & Cancer, 61(4), 636-642. View in Pubmed

Alrazzak, M.A., Brathwaite, C.D., Restrepo, R., Khatib, Z.A. (2013). Plasma Cell Granuloma of the Lung in the Differential Diagnosis of Pulmonary Nodules in a Child with Acute Lymphoblastic Leukemia. The Internet Journal of Oncology, 9(1), . http://ispub.com/IJO/9/1

Vrotsos, E., Soaita, M., Khatib, Z.A., Brathwaite, C.D., Filipovich, A., Robinson, M.J., Castellano-Sanchez, A. (2013). Atypical clinical presentation of primary hemophagocytic lymphohistiocytosis with a novel perforin1 gene mutation. Journal of Hematopathology, 6(2), 105-108.

Khatib, Z.A., Geng, W. (2013). Chemotherapy in the management of retinoblastoma. London. Retinoblastoma: Clinical Advances and Emerging Treatment Strategies. View in Pubmed

De Angulo, G., Nair, S., Lee, V., Khatib, Z., Ragheb, J., Sandberg, D. (2013). Nonoperative management of solitary eosinophilic granulomas of the calvaria. Journal of Neurosurgery. Pediatrics, 12(1), 1-5. View in Pubmed

Alghamdi, S., Castellano-Sanchez, A., Brathwaite, C., Shimizu, T., Khatib, Z., Bhatia, S. (2012). Strong desmin expression in a congenital desmoplastic infantile ganglioglioma mimicking pleomorphic rhadomyosarcoma: a case report including ultrastructural and cytogenetic evaluation and review of the literature. Child's Nervous System, 28(12), 2157-2162. View in Pubmed

Kirton, A., Armstrong-Wells, J., Chang, T., Deveber, G., Rivkin, M.J., Hernandez, M., Carpenter, J., Yager, J.Y., Lynch, J.K., Ferriero, D.M.; International Pediatric Stroke Study Investigators (2011). Symptomatic neonatal arterial ischemic stroke: the International Pediatric Stroke Study. Pediatrics, 128(6), e1402-e1410. View in Pubmed

Jordan, L.C., Rafay, M.F., Smith, S.E., Askalan, R., Zamel, K.M., deVeber, G., Ashwal, S.; International Pediatric Stroke Study Group (2010). Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study. Journal of Pediatrics, 156(5), 704-710. View in Pubmed

Kram, D.E., Brathwaite, C.D., Khatib, Z.A. (2010). Bilateral conjunctival extranodal marginal zone B-cell lymphoma. Pediatric Blood & Cancer, 55(7), 1414-1416. View in Pubmed

Ambati, S., Chamyan, G., Restrepo, R., Escalon, E., Fort, J., Pefkarou, A., Khatib, Z. A., (2008). Rosai-Dorfman disease following bone marrow transplantation for pre-B cell acute lymphoblastic leukemia. Pediatric Blood & Cancer, 51(3), 433-435. View in Pubmed


A physician identified with a Nicklaus Children’s Pediatric Specialists logo is an employee of Nicklaus Children's Health System. All other physicians listed on the website are in private medical practices.