What is Loeys-Dietz syndrome?

Also known as: LDS.

Loeys-Dietz syndrome is a rare genetic disorder (from a gene mutation or an inherited abnormality from one parent) that negatively affects the formation of a child’s connective tissue (the fibers, ground substance and cells immersed in body water) that surrounds, supports and protects all tissues and organs of the body. Problems that result therefore occur in many parts of the body. Perhaps the most dangerous complications of Loeys-Dietz syndrome are dilatation/twisting of blood vessels called aneurysms, and splitting of the major artery that comes out of the heart (aortic dissection). It can also result in loose joints or skin and cause problems with skull and bones, and part of the bowel, among others.

Reviewed by: Jack Wolfsdorf, MD, FAAP

This page was last updated on: 1/29/2019 3:21:13 PM

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