What is Li-Fraumeni syndrome?

Also known as: LFS- TP53 gene mutation.

Li-Fraumeni syndrome is a genetic disorder that increases the risk of getting certain forms of cancer in children and adults. Breast cancer, bone cancer and soft tissue sarcomas are a few of the common cancers that result from Li-Fraumeni syndrome. A particular brain tumor – choroid plexus carcinoma- may occur in young infants as well as tumors of the adrenal gland.

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Reviewed by: Ziad A Khatib, MD

This page was last updated on: 1/29/2019 3:21:13 PM