What are Innate Immunity Disorders?

Also known as: innate immune defects, innate immunity, primary immunodeficiency diseases

The body’s immune system has two different types of responses to foreign invaders

  • The innate immune system refers to a set of cells that respond as a nonspecific response to infections without any additional specialization or “training,” (these include neutrophils, monocytes, natural killer cells (NK), basophils and mast cells, complement proteins and others.

  • The adaptive or acquired immune system are the specific response to an infection with cells that adapt and tailor their response to specific intruders over time (T-cells and B-cells).

Primary immunodeficiency diseases are those where the body’s immune system is missing or does not function properly. They can be divided into those involving the innate and adaptive systems.

Reviewed by: Jack Wolfsdorf, MD, FAAP

This page was last updated on: 1/29/2019 3:21:13 PM

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