Of 3 phenotypes described ("Cluster 1: "nonatopic uncontrolled severe viral-induced wheezing"; Cluster 2: "multiple wheezing with multiple atopic allergic comorbidities" and Cluster 3: "mild episodic viral-induced wheeze"), the TT-genotype (homozygous/dominant) of IL-4 rs2070874 (Interkeukin-4 inflammatory cytokine - rs gene variant polymorphism) is the only one significantly associated with the Cluster 1 clinical presentation of non-atopic severe viral-induced wheezing indicating the importance of this group of cytokines in the mediation of the immune system's inflammatory response to viral infections.
Published on: 09/26/2017
Viral induced wheezing commonly occurs in children <3 years of age and may recur with each viral infection potentially lasting many weeks. Many (>50%) will outgrow it by pre-school age though some may go on to develop asthma.
A study of 317 children (mean age: 21.5 months) examined the 16 single nucleotide polymorphisms (SNPs) linked to asthma or atopy and examined groupings associated with clinical presentation (phenotypes).