Fecal samples from 36 preterm infants with LOS assessed by electronic nose technology (volatile compounds cause the smell of sweat, blood, urine, feces, etc. and are an indicator of the composition and activity of intestinal microbial metabolism) can be differentiated from matched normal controls up to 3 days prior to the clinical onset of the disease. Stool VOC profiling is clinically feasible and is potentially an exciting area for future studies in at risk infants.
Published on: 09/09/2017
Diagnosis sepsis early in infants remains problematic. Several studies have indicated that gut microbiota composition is altered days before the clinical onset of sepsis. Unfortunately at present microbiota analysis as an early diagnostic biomarker is not clinically feasible due to a number of factors.
A prospective multicenter study examined daily fecal volatile organic compounds (VOCs) (as a non-invasive biomarkers) from infant (gestational age >30 weeks) stool samples up to 5 days before diagnosis of LOS to predict LOS at a preclinical stage.