CLOVES Syndrome

Also known as: CLOVE syndrome, CS, congenital lipomatous overgrowth, vascular malformations, epidermal nevis and scoliosis/skeletal/spinal anomalies.

What is CLOVES syndrome?

CLOVES syndrome is a very rare disorder, one of a group of congenital (present at birth) “overgrown syndromes”, that is characterized by the presence of several problems together. CLOVES stands for:
  • Congenital
  • Lipomatous
  • Overgrowth
  • Vascular
  • Epidermal Nevis
  • Spinal / Skeletal / Anomalies / Scoliosis


This disorder includes: large collections (masses) of fatty tissue, complex vascular malformations, patches of overgrown skin, spine problems, other bone and joint abnormalities and stiff or weak muscles.

 

What causes CLOVES syndrome?

CLOVES syndrome is due to a genetic mutation that occurs while a fetus is developing in the womb. It does not appear to run in families.

 

What are signs/the symptoms of CLOVES syndrome?

Signs and symptoms of CLOVES syndrome include:

  • Soft fatty masses seen at birth, affecting one or both sides of the body, frequently located in the abdomen, buttocks, flanks, armpits, and back.
  • Vascular abnormalities, such as include dilated veins on arms and legs, and abnormalities of lymphatic vessels.
  • Large wide hands or feet and other abnormalities of the arms and legs are common.
  • Skin birthmarks
  • Spinal anomalies like scoliosis (curved spine)
  • Kidney problems

 

What are CLOVES syndrome care options?

As there are a wide range of problems and complications, a team of pediatric specialists and subspecialists is required to deliver optimal care.


Reviewed by: Jack Wolfsdorf, MD

This page was last updated on: 6/12/2018 11:32:39 AM

Weekly Support Programs

Brain Wellness: Yoga for Kids

Participants will learn to optimize neurological potential across the developing age and care continuum, to provide other treatment modalities to optimize results, to provide options for our patients and families, to provide options for our patients and families, and more! Learn more.

From the Newsdesk

Mason's Story: Nicklaus Children's Makes the Difference for Child with Traumatic Brain Injury
Seeing a baby boy intubated, hooked up to a maze of machines, and with IV pumps snaking out of his tiny arms is an incredibly heartbreaking and terrifying experience. The Nicklaus Children’s staff was not only caring and friendly, but knowledgeable and explained everything to us in detail. Meeting the neurosurgery team brought us great comfort because they were confident and calm—they won our trust immediately.
Infant flown from Puerto Rico days after Hurricane Maria for Lifesaving Surgery
Naialee Perez had just given birth to her first child, a baby boy named Liam, when a category five hurricane was making its way towards her hometown in the island of Puerto Rico. Liam was on a ventilator and undergoing treatment for a congenital heart defect in Hospital del Niño in San Juan while those on the island prepared for what would become one of the most catastrophic hurricanes in its history.