CLOVES Syndrome

Also known as: CLOVE syndrome, CS, congenital lipomatous overgrowth, vascular malformations, epidermal nevis and scoliosis/skeletal/spinal anomalies.

What is CLOVES syndrome?

CLOVES syndrome is a very rare disorder, one of a group of congenital (present at birth) “overgrown syndromes”, that is characterized by the presence of several problems together. CLOVES stands for:
  • Congenital
  • Lipomatous
  • Overgrowth
  • Vascular
  • Epidermal Nevis
  • Spinal / Skeletal / Anomalies / Scoliosis


This disorder includes: large collections (masses) of fatty tissue, complex vascular malformations, patches of overgrown skin, spine problems, other bone and joint abnormalities and stiff or weak muscles.

 

What causes CLOVES syndrome?

CLOVES syndrome is due to a genetic mutation that occurs while a fetus is developing in the womb. It does not appear to run in families.

 

What are signs/the symptoms of CLOVES syndrome?

Signs and symptoms of CLOVES syndrome include:

  • Soft fatty masses seen at birth, affecting one or both sides of the body, frequently located in the abdomen, buttocks, flanks, armpits, and back.
  • Vascular abnormalities, such as include dilated veins on arms and legs, and abnormalities of lymphatic vessels.
  • Large wide hands or feet and other abnormalities of the arms and legs are common.
  • Skin birthmarks
  • Spinal anomalies like scoliosis (curved spine)
  • Kidney problems

 

What are CLOVES syndrome care options?

As there are a wide range of problems and complications, a team of pediatric specialists and subspecialists is required to deliver optimal care.


Reviewed by: Jack Wolfsdorf, MD

This page was last updated on: 6/12/2018 11:32:39 AM

Weekly Support Programs

Brain Wellness: Yoga for Kids

Participants will learn to optimize neurological potential across the developing age and care continuum, to provide other treatment modalities to optimize results, to provide options for our patients and families, to provide options for our patients and families, and more! Learn more.

From the Newsdesk

Fetal Care Center Special Delivery Unit Expected to Open in Summer of 2019
We are pleased to announce the Fetal Care Center’s special delivery unit is expected to open in the summer of 2019. This special delivery unit will offer a smooth transfer of care and access to our network of pediatric subspecialists and our three pediatric intensive care units.
Li Travels all the way from Shanghai to Nicklaus Children’s for Management of his Complex Heart Condition
Li Hongyang, 37, traveled all the way from his hometown of Shanghai China to find the best possible care for his complex heart condition. What he did not expect is that he would receive his lifesaving treatment at a children’s hospital.