Multiple Endocrine Neoplasia Type 2

Also known as: MEN2, MEN 2A syndrome, MEN 2B syndrome.

What is multiple endocrine neoplasia type 2?

Multiple endocrine neoplasia type 2 is a disease that affects several glands throughout the body, including the thyroid, parathyroid and adrenal gland. It causes tumors in these glands and also imbalances in the hormones that the glands produce. It differs from multiple endocrine neoplasia type 1 based on the genetic mutation that causes it, and some of the glands that it impacts.

What causes multiple endocrine neoplasia type 2?

Multiple endocrine neoplasia type 2 is the result of a genetic mutation. The disease is passed down from parents to children.

What are the symptoms of multiple endocrine neoplasia type 2?

The tumors that are typical of multiple endocrine neoplasia type 2 lead to hormone imbalances, which in turn produce symptoms such as kidney stones, bone loss, bone pain, constipation, indigestion, fatigue and other symptoms. Though the tumors are usually benign, they can increase the risk of cancer developing over time.

What are multiple endocrine neoplasia type 2 care options?

Surgery to remove the tumor is often the recommended treatment for multiple endocrine neoplasia type 2. Medications can also help with many of the symptoms related to the disease.

Close follow up and monitoring with blood tests and ultrasound and MRI is essential to detect any tumor at an early stage.


Reviewed by: Ziad A Khatib, MD

This page was last updated on: 5/23/2018 3:00:13 PM

From the Newsdesk

Bianca’s Journey to Being Pain Free
Bianca suffered from pain and a severe bowleg deformity for many years as a result of Blount’s disease, a growth disorder that affects the bones in children and young adults.
September Patient of the Month: Mateo
When Mateo was just two years old, his parents were shocked to discover that their toddler developed leukemia. They met with the hematology and oncology specialists at Nicklaus Children’s Hospital and began a treatment protocol that brought Mateo back to health—along with some entertainment from his spirited little sister! Mateo, now 10, is a healthy, typical kid who loves running around with his friends.