Juvenile Myelomonocytic Leukemia
Also known as: JMML, juvenile chronic myeloid leukemia, chronic myelomonocytic leukemia of infancy, infantile monosomy 7 syndrome
What is juvenile myelomonocytic leukemia?
JMML is a rare, serious chronic form of cancer
of the blood in children (frequently boys), aged less than 4 years (average age: 2 years).
What causes juvenile myelomonocytic leukemia?
It appears that though the causes are unknown, sporadic or inherited genetic changes in a particular cell in the bone marrow (stem cell), gives rise to a blood type called an immature monocyte which increases uncontrollably in the bone marrow, eventually preventing the bone marrow producing the other blood cell types (red blood cells, white blood cells and platelets). Children with Noonan syndrome or neurofibromatosis type 1, are at increased risk of developing JMML.
What are the symptoms of juvenile myelomonocytic leukemia?
Symptoms of JMML can include fever, pale skin (anemia), frequent infections, bruising and abnormal bleeding, a swollen abdomen due to a large spleen and liver, swollen lymph nodes, bone and joint pain, and cough/difficulty breathing.
What are juvenile myelomonocytic leukemia care options?
Chemotherapy and radiation may be used before stem cell transplantation of the bone marrow, the only cure for JMML.
Reviewed by: Jack Wolfsdorf, MD, FAAP
This page was last updated on: 5/23/2018 2:28:46 PM
Camp U.O.T.S. is an annual weeklong, overnight camp for children with cancer and blood disorders who are treated at Nicklaus Children’s Hospital.
Learn more and register
From the Newsdesk
More than two dozen children attended the Bear Hug camp at Nicklaus Children's last week. This day camp is for siblings of pediatric cancer patients to encourage socialization among peers and help them gain insight on their siblings' care journey.
On this very same day nine years ago, Daniella Alvarez was diagnosed Teratoid Rhabdoid Tumor (ATRT), a rare and aggressive type of brain cancer. The news came on June 26, 2009, her second birthday. Daniella endured years of brain surgeries, aggressive chemotherapies, radiation, imaging scans, multiple visits to intensive care at Nicklaus Children’s Hospital. She is now cancer free thanks to a pediatric clinical trial made possible through research funding.