Juvenile Myelomonocytic Leukemia
Also known as: JMML, juvenile chronic myeloid leukemia, chronic myelomonocytic leukemia of infancy, infantile monosomy 7 syndrome
What is juvenile myelomonocytic leukemia?
JMML is a rare, serious chronic form of cancer
of the blood in children (frequently boys), aged less than 4 years (average age: 2 years).
What causes juvenile myelomonocytic leukemia?
It appears that though the causes are unknown, sporadic or inherited genetic changes in a particular cell in the bone marrow (stem cell), gives rise to a blood type called an immature monocyte which increases uncontrollably in the bone marrow, eventually preventing the bone marrow producing the other blood cell types (red blood cells, white blood cells and platelets). Children with Noonan syndrome or neurofibromatosis type 1, are at increased risk of developing JMML.
What are the symptoms of juvenile myelomonocytic leukemia?
Symptoms of JMML can include fever, pale skin (anemia), frequent infections, bruising and abnormal bleeding, a swollen abdomen due to a large spleen and liver, swollen lymph nodes, bone and joint pain, and cough/difficulty breathing.
What are juvenile myelomonocytic leukemia care options?
Chemotherapy and radiation may be used before stem cell transplantation of the bone marrow, the only cure for JMML.
Reviewed by: Jack Wolfsdorf, MD, FAAP
This page was last updated on: 5/23/2018 2:28:46 PM
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Meet our July Patient of the Month, Lacy. Lacy was only 2 years old when her parents noticed that something was wrong. They took her to various doctors to try to find what could be the cause, Lacy had an 8 cm. tumor in her brain, occupying most of the lower part of her head.
From the Newsdesk
Children being treated by the Cancer & Blood Disorders Center, Neuro Oncology Program at Nicklaus Children’s Hospital and their families took part in a holiday celebration.
Dr. Toba N. Niazi, Neurosurgeon, and Dr. Ziad A. Khatib, Hematologist and Oncologist, discuss the second leading cause of cancer in children, brain tumors.